Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1784 | Thyroid cancer | ICEECE2012

Mass spectrometry allows accurate measurement of serum thyroglobulin (Tg) in the presence of anti-thyroglobulin auto-antibodies (TgAB)

Taylor R. , Netzel B. , Theobald J. , Barnidge D. , McIver B. , Algeciras-Schimnich A. , Singh R. , Grebe S.

Background: Serum thyroglobulin (Tg) measurements are one of the main pillars of thyroid cancer follow-up, because of the high organ and disease specificity of Tg in athyrotic patients. However, 20–25% of patients have detectable serum anti-Tg auto-antibodies (TgAB), which might cause false low Tg measurements in immunometric assays (IMA). This can lead to significant challenges in patient management. Measurement of Tg by liquid chromatography-tandem mass spectrometry (LC...